Usnic acid inhibits hypertrophic scarring in a rabbit ear model by suppressing scar tissue angiogenesis
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چکیده
منابع مشابه
Enhanced in Vivo Delivery of 5-Fluorouracil by Ethosomal Gels in Rabbit Ear Hypertrophic Scar Model
Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good water-solubility and biocompatibility. However, there has not been an explicit description of applying EGs as a vehicle for hypertrophic scars treatment. Here, a novel transdermal EGs loaded with 5-fluorouracil (5-FU EGs) was successfully prepared and characterized. The stab...
متن کاملThe effects of collagenase ointment on the prevention of hypertrophic scarring in a rabbit ear scarring model: a pilot study.
UNLABELLED Collagen synthesis and degradation are important in scar maturation. Collagenase has been used for debridement of wounds and treatment of Dupuytren's disease but its effects on scar prevention are unknown. OBJECTIVE The objective of this study was to determine the effect of collagenase ointment on hypertrophic scar prevention by using a rabbit ear-scarring model. METHODS F...
متن کاملLocal Application of Statins Significantly Reduced Hypertrophic Scarring in a Rabbit Ear Model
BACKGROUND We previously showed that intradermal injection of statins is a successful treatment for hypertrophic scarring. Topical application has many advantages over intradermal injection. In this study, we demonstrate the efficacy of topical statin treatment in reducing scar in our validated rabbit ear scar model. METHODS Twenty New Zealand White rabbits were divided into 2 study groups, w...
متن کاملLower energy radial shock wave therapy improves characteristics of hypertrophic scar in a rabbit ear model
The aim of the present study was to investigate the effects of radial extracorporeal shock wave therapy (rESWT) on scar characteristics and transforming growth factor (TGF)-β1/Smad signaling in order to explore a potential modality for the treatment of hypertrophic scars (HS). The HS model was generated in rabbit ears, then rabbits were randomly divided into 3 groups: Lower (L)-ESWT [treated wi...
متن کاملEffect of Mederma on hypertrophic scarring in the rabbit ear model.
Currently accepted conservative treatments of hypertrophic scars are limited to steroid injections, radiation therapy, and silicone occlusive therapy. However, the use of Mederma for these problematic lesions has become quite prevalent in the clinical setting. Little scientific evidence exists to support the efficacy of this product in reducing hypertrophic scars. The aim of this study was to s...
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2018
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2018.06.176